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Can you play with more than 4 people in l4d2?
Yes, you can play with only 2 people in l4d2. In fact, you can play with as few as 1 person if you want. The game is designed to be played with 4 people, but you can play with fewer if you want.
Summary
Yes, you can play l4d2 with as few as 2 people. The game is designed for 4 people, but you can play with fewer if you want.